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Isaac Scientific Publishing
Advances in Food Science and Engineering
Prof. Roberto Fabiani,  University of Perugia, Italy
University of Perugia, Department of Chemistry,
Biology and Biotechnology
Via Elce di Sotto, 8 - 06123 Perugia (Italy)
Research Interests
The scientific activity, has been devoted to the study of both carcinogenic properties
of different environmental pollutants and chemopreventive activities of natural
compounds present in the food stuffs of Mediterranean diet
Selected Publication List
•Fabiani R, Rosignoli P, De Bartolomeo A, Fuccelli R, Morozzi G. Genotoxicity of alkene epoxides on human peripheral blood mononuclear cells and HL60 evaluated by the comet assay. Mutat. Res. 2012; 747(1): 1-6.
•Fabiani R, Sepporta MV, Rosignoli P, De Bartolomeo A, Crescimanno M, Morozzi G. Anti-proliferative and pro-apoptotic activities of hydroxytyrosol on different tumour cells: the role of extracellular production of hydrogen peroxide. Eur. J. Nutr. 2012; 51(4): 456-64.
•Fabiani R, Sepporta MV, Mazza T, Rosignoli P, Fuccelli R, De Bartolomeo A, Crescimanno M, Taticchi A, Esposto S, Servili M, Morozzi G. Influence of Cultivar and Concentration of Selected Phenolic Constituents on the in Vitro Chemiopreventive Potential of Olive Oil Extracts. J. Agric. Food Chem. 2011; 59(15): 8167-8174.
•Fabiani R, Rosignoli P, De Bartolomeo A, Fuccelli R, Servili M, Morozzi G. The production of hydrogen peroxide is not a common mechanism by which olive oil phenols induce apoptosis on HL60 cells. Food Chemistry 2011; 125:1249-1255.
•Fabiani R, Fuccelli R, Pieravanti F, De Bartolomeo A, Morozzi G. Production of hydrogen peroxide is responsible for the induction of apoptosis by hydroxytyrosol on HL60 cells. Mol. Nutr. Food Res. 2009; 53(7): 887-96
•Servili M, Esposto S, Fabiani R, Urbani S, Taticchi A, Mariucci F, Selvaggini R, Montedoro GF. Phenolic compounds in olive oil: antioxidant, health and organoleptic activities according to their chemical structure. Inflammopharmacology 2009; 17(2):76-84.
•Fabiani R, De Bartolomeo A, Rosignoli P, Morozzi G., Cecinato A., Calducci C. Chemical and toxicological characterization of airborne total suspended particulate (TSP) and PM10 organic extracts. PAC 2008; 28: 486-499.
•Rosignoli P, Fabiani R, De Bartolomeo A, Fuccelli R, Pelli MA, Morozzi G. Genotoxic effect of bile acids on human normal and humour colon cells and protection by dietary antioxidants and butyrate. Eur. J. Nutr. 2008: 47(6): 301-309.
•Fabiani R, Rosignoli P, De Bartolomeo A, Fuccelli R, Servili M., Montedoro GF, Morozzi G. Oxidative DNA damage is prevented by extracts of olive oil, hydroxytyrosol, and other olive phenolic compounds in human blood mononuclear cells and HL60 cells. J. Nutr. 2008: 138(8): 1411-1416.
•Fabiani R, Rosignoli P, De Bartolomeo A, Fuccelli R, Morozzi G. Inhibition of cell cycle progression by hydroxytyrosol is associated with upregulation of cyclin-dependent protein kinase inhibitors p21(WAF1/Cip1) and p27(Kip1) and with induction of differentiation in HL60 cells. J. Nutr. 2008: 138(1):42-48.
•Fabiani R., Rosignoli P., De Bartolomeo A., Fuccelli R., Morozzi G. DNA-damaging ability of isoprene and isoprene mono-epoxide (EPOX I) in human cells evaluated with the comet assay. Mutat. Res. 2007: 629(1):7-13.
•Fabiani R., De Bartolomeo A., Rosignoli P., Servili M., Selvaggini R., Montedoro G.F., Di Saverio C., Morozzi G. Virgin olive oil phenols inhibit proliferation of human promyelocytic leukemia cells (HL60) by inducing apoptosis and differentiation. J. Nutr. 2006 136 (3): 614-619.
•Castigli E., Sciaccaluga M., Schiavoni G., Brozzi F., Fabiani R., Gorello P., Gianfranceschi G.L. GL15 and U251 glioblastoma-derived human cell lines are peculiarly susceptible to induction of mitotic death by very low concentrations of okadaic acid. Oncol. Rep. 2006 15: 463-470.
-Fabiani R., De Bartolomeo A. and Morozzi G. Involvement of oxygen free radicals in the serum-mediated increase of benzoquinone genotoxicity. Environ. Mol. Mutagen. 2005 46: 156-163.
•Zampa A, Silvi S, Fabiani R, Morozzi G, Orpianesi C, Cresci A. Effects of different digestible carbohydrates on bile acid metabolism and SCFA production by human gut micro-flora grown in an in vitro semi-continuous culture. Anaerobe 2004 10: 19-26.
•Fabiani R, De Bartolomeo A, Rosignoli P, Servili M, Montedoro GF, Morozzi G. Effect of virgin olive oil phenols on proliferation, cell cycle and apoptosis of tumour cell lines. Eur. J. Public Health 2003; 13(4): 121-122.
•Dolara P, Caderni G, Salvadori M, Morozzi G, Fabiani R, Cresci A, Orpianesi C, Trallori G, Russo A, Palli D. Fecal levels of short-chain fatty acids and bile acids as determinants of colonic mucosal cell proliferation in humans. Nutr. Cancer 2002; 42(2):186-90.
•Fabiani R., De Bartolomeo A., Rosignoli P., Servili M., Montedoro GF. and Morozzi G. Cancer chemoprevention by hydroxytyrosol isolated from virgin olive oil through G1 cell cycle arrest and apoptosi. Eur. J. Cancer Prev. 2002; 11(4): 351-358.
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