Isaac Scientific Publishing

Annals of Advanced Agricultural Sciences

State of Prooxidant and Antioxidant Blood System in Albino Rats under Joint Effect of T-2 Toxin and Salmonellae in the Experiment

Download PDF (240.2 KB) PP. 16 - 25 Pub. Date: August 14, 2017

DOI: 10.22606/as.2017.11003

Author(s)

  • S.V. Shabunin
    State Scientific Institution “All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy” of the Russian Academy of Agricultural Sciences, Voronezh, Russia
  • A.G. Shakhov*
    State Scientific Institution “All-Russian Veterinary Research Institute of Pathology, Pharmacology, and Therapy” of the Russian Academy of Agriculture Sciences,Voronezh, Russia.
  • G.A. Vostroilova
    State Scientific Institution “All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy” of the Russian Academy of Agricultural Sciences, Voronezh, Russia
  • L.Yu. Sashnina
    State Scientific Institution “All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy” of the Russian Academy of Agricultural Sciences, Voronezh, Russia
  • G.N. Bliznetsova
    State Scientific Institution “All-Russian Veterinary Research Institute of Pathology, Pharmacology and Therapy” of the Russian Academy of Agricultural Sciences, Voronezh, Russia

Abstract

Current experimental research on albino rats has studied the effect of salmonellae and T- 2 toxin on indices of lipid peroxidation (LPO) and antioxidant protection. Joint effect of bacteria and toxicant, especially in a dose of 560.0µg/kg, was characterized by a more evident increase of integral index of blood and liver LPO – malonic dialdehyde (MDA) by 1.7 and 4.4 times, respectively, and also by exhaustion of antioxidant system (AOS) in animals’ organisms comparing with the situation when the animals were separately contaminated. That was proved by the decrease of catalase activity by 24.7% and vitamin E content – by 43.6% in them. The results obtained demonstrated that salmonella infection against the background of intoxication with T-2 toxin significantly disturbed prooxidant-antioxidant balance in the organism that was the most important mechanism for the oxidative stress development.

Keywords

Lipid peroxidation, malonic dialdehyde, antioxidant system, catalase, glutathione peroxidase, vitamins A and E, T-2 toxicosis, salmonellosis, albino rats.

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