Isaac Scientific Publishing

Modern Organic Chemistry Research

Synthesis of Tetrazole Regioisomers of Biphenyl as ACE Inhibitors

Download PDF (570.6 KB) PP. 48 - 58 Pub. Date: April 20, 2017

DOI: 10.22606/mocr.2017.22003

Author(s)

  • Gangadhar Y. Meti
    Department of Studies in Chemistry, Karnatak University, Pavate Nagar, Dharwad - 580003, India
  • Ravindra R. Kamble*, Mahadev N. Kumbar, Saba Kauser J. Shaikh, Atulkumar A.Kamble, Hirehalli. C. Devarajegowda, Praveen K. Bayannavar*

    Department of Physics, Yuvaraja College, University of Mysore, Mysuru – 570005, India

Abstract

Novel angiotensin converting enzyme (ACE) inhibitors were designed based on the structure of commercially available sartans and synthesized by N-alkylation of 5-substituted-1H-tetrazole with 4'-(bromomethyl)-biphenyl-2-carbonitrile gave 1,5- and 2,5- regioisomers of tetrazole. The nitrile group appended to biphenyl nucleus was converted into tetrazole and later the tetrazole was ring transformed into 1,3,4-oxadiazole. The synthesized compounds were screened for the ACE inhibition and some of the compounds exhibited significant results.

Keywords

Biphenyl, tetrazole, N-alkylation, regioisomers, 1,3,4-Oxadiazole, ring transformation, ACE inhibition

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