Modern Organic Chemistry Research

Download PDF (310.1 KB) PP. 41 - 47 Pub. Date: April 20, 2017

DOI: 10.22606/mocr.2017.22002

• Aleksandra Wojciechowska^*
  Poznan University of Technology, Institute of Chemical Technology and Engineering, Berdychowo St. 4, 60-965 Poznan, Poland
• Karolina Wieszczycka
  
  Poznan University of Technology, Institute of Chemical Technology and Engineering, Berdychowo St. 4, 60-965 Poznan, Poland
• Grzegorz Framski
  
  Institute of Bioorganic Chemistry Polish Academy of Science, Noskowskiego St. 12,14, 61-704 Poznan, Poland

The present study described a detailed investigation of the synthesis of novel quaternary pyridinium salts: derivates of 1-(3-pyridine)undecane-1-one (1-propyl-3-undecanoylpyridinium bromide and 1-propyl-3-undecanoylpyridinium chloride) and N-decyloxypyridine-3-carboximidamide (3-[1-(N-decyloxyimine)ethyl]-1-propylpyridinium chloride and 3-[1-(N-decyloxyimine)ethyl]-1-propylpyridinium bromide). The structures of the products were confirmed by spectral(1H-NMR, 13C-NMR, FT-IR) analysis, mass spectrometry methods. Estimation of the pharmacotherapeutic potential has been accomplished for synthesized compounds on the basis of Prediction of Activity Spectra for Substances (PASS programe).

Quaternary pyridinium salts, synthesis, quarterisation reaction, O-alkylation, prediction of activity

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